Protein-Ligand Interactions

Frontmatter — Preface — Section I. General — Letter from J. Wyman to the Members of the Symposium — Concerted Changes in an Allosteric Macromolecule — Ligand Interactions in Globular Proteins — Discussion — Ligand Binding to Enzyme Complexes — Discussion — Properties of Polymeric Proteins Bound to Solid Matrices: Subunit Exchange Chromatography — Discussion — Contributions of Aromatic Amino Acid Residues to the Optical Activity of Protein-Ligand Complexes — Discussion — Section II. Enzymes — The Architecture of the Coenzyme Binding Domain in Dehydrogenases as Revealed by X-Ray Structure Analysis — Discussion — The Interaction of Glutamate Dehydrogenase with a Coenzyme Analog — Discussion — The Interaction of Adenosine Triphosphate and its Analogs with Myosin and the Modification by Actin — Discussion — Isolation of a Guanylnucleotide Binding Protein from Pigeon Erythrocyte Membranes — Discussion — On the Binding of Isoleucine and Related Amino Acids to Isoleucyl-tRNA Synthetase from Escherichia Coli MRE 600 — Discussion — The Effect of Small Molecules on the Affinity of Individual Chains in Hemoglobin and on its Cooperativity — Discussion — Cooperative Interactions without Symmetry or Subunits — Discussion — A Nuclear Magnetic Resonance Study of Activator Binding by Carboxypeptidase A — Discussion — Section III. Repressors — Lactose Operator Sequences and the Action of Lac Repressor — Discussion — The Active Sites of Lac Repressor — Discussion — Lac Repressor — Discussion — The Use of Suppressed Nonsense Mutations to Generate Altered Lac Repressor Molecules — Discussion — Effect of Alterations in Lac Operator DNA on Repressor Binding — Discussion — Interaction of Lac Repressor with Non-Specific DNA Binding Sites — Discussion — Section IV. Receptors — Binding and Functional States of the Cholinergic Receptor Protein from Torpedo Marmorata — Discussion — Subunit Structure and Binding Sites of the Acetylcholine Receptor — Discussion — Further Characterization of Purified Acetylcholine Receptor and its Incorporation into Phospholipid Vesicles — Discussion — Structural and Functional Studies of an Acetylcholine Receptor — Discussion — Section V. Antibodies, Drugs and Metabolites — Antibody Combining Sites as a Model for Molecular Recognition — Discussion — Antibiotic Action on Enzymes Involved in Peptidoglycan Synthesis — Discussion — Problems in Studying Protein Binding with Regard to the Interaction of Steroids with a Specific Binding Globulin — Discussion — The Interaction of Low-Molecular Compounds with Serum Albumin as Measured by Optical Methods. Circular Dichroism of Bilirubin-Human Serum Albumin Complexes in the Presence of Alcohols in Aqueous Solution — Discussion — Section VI. Detergents and Electrolytes — The Nature of Specific and Non-Specific Interactions of Detergents with Proteins: Complexing and Unfolding — Discussion — Interaction of Detergents with Proteins: Effect of Counter Ions on the System Ferrimyoglobin- Laurylpyridinium Halides in Aqueous Medium — Discussion — Influence of Ions on the Kinetics of Cooperative Conformational Changes in Globular Proteins — Discussion — Neutral Salt Effects on the Conformational Stability of Biological Macromolecules — Discussion — Concluding Remarks — Index of Contributors — Subject Index — Backmatter