Autor: Flims 1987 Workshop on Unconjugated Pterins and Related Biogenic Amines 1

Frontmatter -- PREFACE -- ACKNOWLEDGEMENTS -- CONTENTS -- In Memoriam ALOIS NIEDERWIESER (1935 - 1987) / Curtius, H.-Ch. -- SECTION A: CHEMISTRY AND ANALYSIS OF PTERINS -- HOMOGENEOUS CATALYTIC HYDROGENATION OF L-BIOPTERIN: INFLUENCE OF THE CHIRALITY OF THE SIDE CHAIN AND THE CATALYST ON ITS DIASTEREOSELECTIVE INDUCTION / Antoulas, S. / Viscontini, M. -- SYNTHESIS OF D-NEOPTERIN-3'-PHOSPHATES / Zagalak, B. / Neuheiser, F. / Bosshard, R. / Redweik, U. -- 5-ALKYL-5.6.7.8-TETRAHYDROBIOPTERINS / Kaiser, A. -- MASS SPECTROMETRIC INVESTIGATIONS OF PTERIDINES / Kuster, Th. / Niederwieser, A. -- THE STRUCTURAL CHARACTERIZATION OF 6-PYRUVOYL TETRAHYDROPTERIN BY FAST ATOM BOMBARDMENT MASS SPECTROMETRY WITH ONE- AND TWO-DIMENSIONAL MASS ANALYSIS (FAB/MS AND FAB/MSMS) / Richter, W.J. / Raschdorf, F. / Dahinden, R. / Niederwieser, A. / Curtius, H.-Ch. / Leimbacher, W. / Kuster, Th. -- SECTION Β: BIOCHEMISTRY AND METABOLISM OF PTERINS -- TETRAHYDROBIOPTERIN: OTHER PHYSIOLOGICAL ROLES IN ADDITION TO AROMATIC AMINO ACID HYDROXYLATION? / Milstien, Sheldon -- 1H-NMR STUDIES WITH TETRAHYDROBIOPTERINS, EVIDENCE FOR THE STRUCTURE OF 6-PYRUVOYLTETRAHYDROPTERIN, AN INTERMEDIATE IN THE BIOSYNTHESIS OF TETRAHYDROBIOPTERIN / Ghisla, S. / Steinerstauch, P. / Hasler, Th. / Blau, N. / Curtius, H.-Ch. -- PURIFICATION OF 6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE FROM SALMON LIVER / Hasler, Th. / Niederwieser, A. / Curtius, H.-Ch. -- PURIFICATION OF 6-PYRUVOYL TETRAHYDROPTERIN 2'-KETO REDUCTASE FROM HUMAN LIVER / Curtius, H.-Ch. / Steinerstauch, P. / Leimbacher, W. / Redweik, U. / Takikawa, Sh.-I. / Ghisla, S. -- HUMAN GTP CYCLOHYDROLASE I: PURIFICATION AND PREPARATION OF MONOCLONAL ANTIBODIES / Schoedon, G. / Niederwieser, A. / Curtius, H.-Ch. -- DIHYDROMONAPTERIN TRIPHOSPHATE: OCCURRENCE, ANALYSIS, AND EFFECT ON TETRAHYDROBIOPTERIN BIOSYNTHESIS in vivo AND in vitro / Blau, N. / Steinerstauch, P. / Redweik, U. / Pfister, K. / Schoedon, G. / Kierat, L. / Niederwieser, A. -- BIOSYNTHESIS OF PTERIDINES AND DEAZA FLAVINS IN METHANOGENIC BACTERIA / Schwarzkopf, B. / Le Van, Q. / Eisenreich, W. / Keller, P. J. / Floss, H. G. / Bacher, A. -- TETRAHYDROBIOPTERIN BIOSYNTHESIS AND PTERIDINE METABOLISM IN CELLS OF THE BLOOD SYSTEM, LYMPHOID TISSUES AND IN BIOLOGICAL FLUIDS / Andondonskaja-Renz, B. / Zeitler, H.-J. -- MODIFIED PTERIPINE SYNTHESIS IN TRANSFORMED CELL LINES AND DURING HEAT SHOCK / Seidl, J. / Przybylski, M. / Meinschad, Ch. / Ziegler, I. -- DISEASE ASSOCIATED ALTERATIONS OF PTERIN BIOSYNIHESIS: ENHANCEMENT IN INFLAMMATORY DISEASE, HEMOPOIETIC REGENERATION AND ENDOTOXINEMIA / Huber, Ch. / Herold, M. / Troppmair, J. / Rokos, H. -- METABOLISM OF PTERINS IN THE CELLULAR IMMUNE SYSTEM OF MAN AND MOUSE / Schoedon, Gabriele / Niederwieser, Alois / Curtius, Hans-Christoph / Fontana, Adriano / Troppmair, Jacob / Huber, Christoph -- TETRAHYDROBIOPTERIN SYNTHESIS IS TRIGGERED BY INTERLEUKIN 2 BINDING AND MODULATES RECEPTOR AFFINITY / Ziegler, Irmgard -- KINETICS OF PRODUCTION AND RELEASE OF NEOPTERIN. COMPARISON OF HUMAN PBMC WITH THE PERMANENT MONOCYTIC CELL LINE U937 AND ITS SUBCLONES. / Rokos, K. / Kunze, R.O.F. / Koch, Μ.A. / Rokos, H. / Nilsson, K. -- SECTION D: PTERINS IN DIFFERENT DISEASES -- VARIATIONS OF NEOPTERIN, DIHYDRONEOPTERIN AND IMMUNOLOGICAL PARAMETERS DURING PHYSICAL EXERCISE (JOGGING) / Rokos, H. / Rokos, K. / Kunze, R.O.F. -- BIOPTERIN AND NEOPTERIN IN PLASMA AND LYMPHO-MONONUCLEAR BIOPTERIN IN GRAFT VERSUS HOST DISEASE AND INFECTION AFTER BONE MARROW TRANSPLANTATION. / Fink, M. / Nüssler, V. / Demtröder, Κ. / Höniges, Ε. / Kolb, H.J. / Ziegler, I. -- EFFECTS OF ΡIRENZEPINE, ACICLOVIR AND TRIMETHOPRIM ON PTERINS IN BLOOD CELLS AND PLASMA / Fink, M. / Nüssler, V. / Demtröder, Κ. / Höniges, Ε. / Goldberg, Μ. -- SECTION Ε: TETRAHYDROBIOPTERIN DEFICIENCIES -- HETEROGENEITY OF TETRAHYDROBIOPTERIN DEFICIENCY / DHONDT, Jean-Louis -- PRENATAL DIAGNOSIS OF TETRAHYDROBIOPTERIΝ DEFICIENCY / Blau, N. / Niederwieser, A. / Curtius, H.Ch. / Leimbacher, W. / Kierat, L. / Matasovic, A. / Staudenmann, W. / Ozalp, I. -- SEPIAPTERIN REDUCTASE IN HUMAN AMNIOCYTES, SKIN FIBROBLASTS, CHORIONIC VILLI AND STIMULATED MONONUCLEAR BLOOD CELLS. / Ferré, J. / Naylor, E.W. -- IMPAIRED BIOPTERIN SYNTHESIS IN A PATIENT WITH MILD HYPERPHENYLALANINEMIA. A NEW VARIANT ? / Dhondt, J.L. / Forzy, G. / Hayte, J.M. / Guibaud, P. / Rolland, M.O. / Dorche, C. / Andre, S. -- DIHYDROPTERIDINE REDUCTASE ACTIVITY IN FETAL TISSUES / Bracco, G. / Iavarone, A. / Pagliardini, S. / Levis, F. / Guardamagna, O. / Ferraris, S. / Ponzone, A. -- MOLECULAR ANALYSIS OF HUMAN DIHYDROPTERIDINE REDUCTASE AND DIHYDROPTERIDINE REDUCTASE DEFICIENCY / Cotton, R.G.H. / Hutchison, W.M. / Wake, S. / Jennings, I.G. / McAdam, W.J. / Danks, D.M. / Dahl, H.-H.M. -- FATE OF PERIPHERALLY ADMINISTERED TETRAHYDROBIOPTERIΝ IN CONGENITAL TETRAHYDROBIOPTERIΝ DEFICIENCY / Ferraris, S. / Guardamagna, O. / Bonetti, G. / Bracco, G. / Leone, L. / Ponzone, A. / Niederwieser, A. -- 6-PYRUVOYL-TETRAHYDROPTERIN SYNTHASE DEFICIENCY: THERAPEUTIC TRIAL WITH TWO DIFFERENT SYNTHETIC PTERIN ANALOGUES IN THREE PATIENTS / Leupold, D. / Lehmann, H. / Curtius, H.Ch. / Niederwieser, A. -- PLACENTAL BARRIER IN MOTHER-TO-FETUS TRANSFER OF TETRAHYDROBIOPTERIN IN HUMANS / Ponzone, A. / Ferraris, S. / Biasetti, S. / Dianzani, I. / Guardamagna, O. / Kierat, L. / Niederwieser, A. -- SECTION F: MONOAMINE NEUROTRANSMITTERS AND ENZYMES -- THERAPEUTIC POTENTIAL OF TETRAHYDROBIOPTERIN THERAPY IN NEUROLOGICAL AND PSYCHIATRIC ILLNESS / Levine, Robert A. -- ORGANIZATION OF THE CATALYTIC AND REGULATORY SITES OF RAT LIVER PHENYLALANINE HYDROXYLASE / Parniak, Michael A. -- IMMUNOCHEMICAL STUDIES OF PHENYLALANINE HYDROXYLASE / Cotton, R. G. H. / Jennings, I. G. / McAdam, W. / Smith, S. -- INFLUENCE OF SUBSTRATES AND COFACTORS ON TYROSINE HYDROXYLASE / Kuhn, D.M. -- MECHANISM OF ACTIVATION OF TRYPTOPHAN 5-MONOOXYGENASE BY MERCAPTIDES / Hasegawa, H. / Ichiyama, A. -- EFFECTS OF TETRAHYDROPTERINS ON DOPA PRODUCTION IN VITRO AND IN VIVO / Bräutigam, M. / Pfleiderer, W. -- PTERINS AND MONOAMINE METABOLITES IN CEREBROSPINAL FLUID / DHONDT, J.L. / FORZY, G. / HAYTE, J.M. / FARRIAUX, J.P. / LARGILLIERE, C. -- AUTHOR INDEX -- SUBJECT INDEX -- LIST OF PARTICIPANTS

Frontmatter -- PREFACE -- ACKNOWLEDGEMENTS -- CONTENTS -- In Memoriam ALOIS NIEDERWIESER (1935 - 1987) / Curtius, H.-Ch. -- SECTION A: CHEMISTRY AND ANALYSIS OF PTERINS -- HOMOGENEOUS CATALYTIC HYDROGENATION OF L-BIOPTERIN: INFLUENCE OF THE CHIRALITY OF THE SIDE CHAIN AND THE CATALYST ON ITS DIASTEREOSELECTIVE INDUCTION / Antoulas, S. / Viscontini, M. -- SYNTHESIS OF D-NEOPTERIN-3'-PHOSPHATES / Zagalak, B. / Neuheiser, F. / Bosshard, R. / Redweik, U. -- 5-ALKYL-5.6.7.8-TETRAHYDROBIOPTERINS / Kaiser, A. -- MASS SPECTROMETRIC INVESTIGATIONS OF PTERIDINES / Kuster, Th. / Niederwieser, A. -- THE STRUCTURAL CHARACTERIZATION OF 6-PYRUVOYL TETRAHYDROPTERIN BY FAST ATOM BOMBARDMENT MASS SPECTROMETRY WITH ONE- AND TWO-DIMENSIONAL MASS ANALYSIS (FAB/MS AND FAB/MSMS) / Richter, W.J. / Raschdorf, F. / Dahinden, R. / Niederwieser, A. / Curtius, H.-Ch. / Leimbacher, W. / Kuster, Th. -- SECTION Β: BIOCHEMISTRY AND METABOLISM OF PTERINS -- TETRAHYDROBIOPTERIN: OTHER PHYSIOLOGICAL ROLES IN ADDITION TO AROMATIC AMINO ACID HYDROXYLATION? / Milstien, Sheldon -- 1H-NMR STUDIES WITH TETRAHYDROBIOPTERINS, EVIDENCE FOR THE STRUCTURE OF 6-PYRUVOYLTETRAHYDROPTERIN, AN INTERMEDIATE IN THE BIOSYNTHESIS OF TETRAHYDROBIOPTERIN / Ghisla, S. / Steinerstauch, P. / Hasler, Th. / Blau, N. / Curtius, H.-Ch. -- PURIFICATION OF 6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE FROM SALMON LIVER / Hasler, Th. / Niederwieser, A. / Curtius, H.-Ch. -- PURIFICATION OF 6-PYRUVOYL TETRAHYDROPTERIN 2'-KETO REDUCTASE FROM HUMAN LIVER / Curtius, H.-Ch. / Steinerstauch, P. / Leimbacher, W. / Redweik, U. / Takikawa, Sh.-I. / Ghisla, S. -- HUMAN GTP CYCLOHYDROLASE I: PURIFICATION AND PREPARATION OF MONOCLONAL ANTIBODIES / Schoedon, G. / Niederwieser, A. / Curtius, H.-Ch. -- DIHYDROMONAPTERIN TRIPHOSPHATE: OCCURRENCE, ANALYSIS, AND EFFECT ON TETRAHYDROBIOPTERIN BIOSYNTHESIS in vivo AND in vitro / Blau, N. / Steinerstauch, P. / Redweik, U. / Pfister, K. / Schoedon, G. / Kierat, L. / Niederwieser, A. -- BIOSYNTHESIS OF PTERIDINES AND DEAZA FLAVINS IN METHANOGENIC BACTERIA / Schwarzkopf, B. / Le Van, Q. / Eisenreich, W. / Keller, P. J. / Floss, H. G. / Bacher, A. -- TETRAHYDROBIOPTERIN BIOSYNTHESIS AND PTERIDINE METABOLISM IN CELLS OF THE BLOOD SYSTEM, LYMPHOID TISSUES AND IN BIOLOGICAL FLUIDS / Andondonskaja-Renz, B. / Zeitler, H.-J. -- MODIFIED PTERIPINE SYNTHESIS IN TRANSFORMED CELL LINES AND DURING HEAT SHOCK / Seidl, J. / Przybylski, M. / Meinschad, Ch. / Ziegler, I. -- DISEASE ASSOCIATED ALTERATIONS OF PTERIN BIOSYNIHESIS: ENHANCEMENT IN INFLAMMATORY DISEASE, HEMOPOIETIC REGENERATION AND ENDOTOXINEMIA / Huber, Ch. / Herold, M. / Troppmair, J. / Rokos, H. -- METABOLISM OF PTERINS IN THE CELLULAR IMMUNE SYSTEM OF MAN AND MOUSE / Schoedon, Gabriele / Niederwieser, Alois / Curtius, Hans-Christoph / Fontana, Adriano / Troppmair, Jacob / Huber, Christoph -- TETRAHYDROBIOPTERIN SYNTHESIS IS TRIGGERED BY INTERLEUKIN 2 BINDING AND MODULATES RECEPTOR AFFINITY / Ziegler, Irmgard -- KINETICS OF PRODUCTION AND RELEASE OF NEOPTERIN. COMPARISON OF HUMAN PBMC WITH THE PERMANENT MONOCYTIC CELL LINE U937 AND ITS SUBCLONES. / Rokos, K. / Kunze, R.O.F. / Koch, Μ.A. / Rokos, H. / Nilsson, K. -- SECTION D: PTERINS IN DIFFERENT DISEASES -- VARIATIONS OF NEOPTERIN, DIHYDRONEOPTERIN AND IMMUNOLOGICAL PARAMETERS DURING PHYSICAL EXERCISE (JOGGING) / Rokos, H. / Rokos, K. / Kunze, R.O.F. -- BIOPTERIN AND NEOPTERIN IN PLASMA AND LYMPHO-MONONUCLEAR BIOPTERIN IN GRAFT VERSUS HOST DISEASE AND INFECTION AFTER BONE MARROW TRANSPLANTATION. / Fink, M. / Nüssler, V. / Demtröder, Κ. / Höniges, Ε. / Kolb, H.J. / Ziegler, I. -- EFFECTS OF ΡIRENZEPINE, ACICLOVIR AND TRIMETHOPRIM ON PTERINS IN BLOOD CELLS AND PLASMA / Fink, M. / Nüssler, V. / Demtröder, Κ. / Höniges, Ε. / Goldberg, Μ. -- SECTION Ε: TETRAHYDROBIOPTERIN DEFICIENCIES -- HETEROGENEITY OF TETRAHYDROBIOPTERIN DEFICIENCY / DHONDT, Jean-Louis -- PRENATAL DIAGNOSIS OF TETRAHYDROBIOPTERIΝ DEFICIENCY / Blau, N. / Niederwieser, A. / Curtius, H.Ch. / Leimbacher, W. / Kierat, L. / Matasovic, A. / Staudenmann, W. / Ozalp, I. -- SEPIAPTERIN REDUCTASE IN HUMAN AMNIOCYTES, SKIN FIBROBLASTS, CHORIONIC VILLI AND STIMULATED MONONUCLEAR BLOOD CELLS. / Ferré, J. / Naylor, E.W. -- IMPAIRED BIOPTERIN SYNTHESIS IN A PATIENT WITH MILD HYPERPHENYLALANINEMIA. A NEW VARIANT ? / Dhondt, J.L. / Forzy, G. / Hayte, J.M. / Guibaud, P. / Rolland, M.O. / Dorche, C. / Andre, S. -- DIHYDROPTERIDINE REDUCTASE ACTIVITY IN FETAL TISSUES / Bracco, G. / Iavarone, A. / Pagliardini, S. / Levis, F. / Guardamagna, O. / Ferraris, S. / Ponzone, A. -- MOLECULAR ANALYSIS OF HUMAN DIHYDROPTERIDINE REDUCTASE AND DIHYDROPTERIDINE REDUCTASE DEFICIENCY / Cotton, R.G.H. / Hutchison, W.M. / Wake, S. / Jennings, I.G. / McAdam, W.J. / Danks, D.M. / Dahl, H.-H.M. -- FATE OF PERIPHERALLY ADMINISTERED TETRAHYDROBIOPTERIΝ IN CONGENITAL TETRAHYDROBIOPTERIΝ DEFICIENCY / Ferraris, S. / Guardamagna, O. / Bonetti, G. / Bracco, G. / Leone, L. / Ponzone, A. / Niederwieser, A. -- 6-PYRUVOYL-TETRAHYDROPTERIN SYNTHASE DEFICIENCY: THERAPEUTIC TRIAL WITH TWO DIFFERENT SYNTHETIC PTERIN ANALOGUES IN THREE PATIENTS / Leupold, D. / Lehmann, H. / Curtius, H.Ch. / Niederwieser, A. -- PLACENTAL BARRIER IN MOTHER-TO-FETUS TRANSFER OF TETRAHYDROBIOPTERIN IN HUMANS / Ponzone, A. / Ferraris, S. / Biasetti, S. / Dianzani, I. / Guardamagna, O. / Kierat, L. / Niederwieser, A. -- SECTION F: MONOAMINE NEUROTRANSMITTERS AND ENZYMES -- THERAPEUTIC POTENTIAL OF TETRAHYDROBIOPTERIN THERAPY IN NEUROLOGICAL AND PSYCHIATRIC ILLNESS / Levine, Robert A. -- ORGANIZATION OF THE CATALYTIC AND REGULATORY SITES OF RAT LIVER PHENYLALANINE HYDROXYLASE / Parniak, Michael A. -- IMMUNOCHEMICAL STUDIES OF PHENYLALANINE HYDROXYLASE / Cotton, R. G. H. / Jennings, I. G. / McAdam, W. / Smith, S. -- INFLUENCE OF SUBSTRATES AND COFACTORS ON TYROSINE HYDROXYLASE / Kuhn, D.M. -- MECHANISM OF ACTIVATION OF TRYPTOPHAN 5-MONOOXYGENASE BY MERCAPTIDES / Hasegawa, H. / Ichiyama, A. -- EFFECTS OF TETRAHYDROPTERINS ON DOPA PRODUCTION IN VITRO AND IN VIVO / Bräutigam, M. / Pfleiderer, W. -- PTERINS AND MONOAMINE METABOLITES IN CEREBROSPINAL FLUID / DHONDT, J.L. / FORZY, G. / HAYTE, J.M. / FARRIAUX, J.P. / LARGILLIERE, C. -- AUTHOR INDEX -- SUBJECT INDEX -- LIST OF PARTICIPANTS